Self-immolative aryl phthalate esters.
نویسندگان
چکیده
We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.
منابع مشابه
Self-immolative phthalate esters sensitive to hydrogen peroxide and light.
Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.
متن کاملEvaluation of the Phthalate Esters in South Indian Women with Endometriosis
Background To evaluate the possible association between phthalate esters (PEs) and the occurrence of endometriosis. Blood samples were collected from 99 infertile women with endometriosis (study group); 135 age-matched women without endometriosis (control group) but with infertility related to tubal defects, fibroids, polycystic ovaries, idiopathic infertility and pelvic inflammatory diseases d...
متن کاملمروری بر تماس با فتالاتها و سمیت آنها
The dialkyl- or alkyl/aryl esters of 1, 2-benzenedicarboxylic acid, which are known as Phthalates, are high-production volume synthetic chemicals and considered as environmental pollutants, due to high production and uses in community, plastics industry and common consuming products. Di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate in the environment. Human exposure with DEHP c...
متن کاملBiological impact of phthalates.
Esters of phthalic acid are chemical agents used to improve the plasticity of industrial polymers. Their ubiquitous use in multiple commercial products results in extensive exposure to humans and the environment. This study investigated cytotoxicity, endocrine disruption, effects mediated via AhR, lipid peroxidation and effects on expression of enzymes of xenobiotic metabolism caused by di-(2-e...
متن کاملتعیین غلظت استرهای فتالات در آب های بطری شده در ظروف پلی اتیلن ترفتالات(PET) تحت شرایط مختلف نگهداری
Background and purpose: Consumption of bottled water is increasing in the world and there are many concerns about the migration of phthalate esters into bottled water. These compounds are risky for consumers. This study investigated the concentration of phthalate esters in bottled water in polyethylene terephthalate containers in different storage conditions. Materials and methods: Bottled wat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 78 2 شماره
صفحات -
تاریخ انتشار 2013